Epigenetics mechanisms and degenerative diseases
نویسندگان
چکیده
منابع مشابه
Epigenetics mechanisms and degenerative diseases
Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms include histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environment interactions. Such epigenetic modifica...
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dinucleotides are the rarest dinucleotides in genomes, Ficz says that 75–85% of these dinucleotides are methylated in mammals (p. 14). However, when they group together to form CpG islands at promoter regions, they are generally unmethylated. Adding that this so-called ‘hypermethylation’ effectively shuts down genes, Ficz says that promoter hypermethylation is rare during development, yet incre...
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ژورنال
عنوان ژورنال: Open Journal of Genetics
سال: 2012
ISSN: 2162-4453,2162-4461
DOI: 10.4236/ojgen.2012.24023